四、代表性研究论文
代表性研究论文
77.Qingzhu Liu, Shuyue Cai, Jiacong Ye, Quan Xie, Rongbin Liu*, Ling Qiu*, Jianguo Lin*. Preclinical evaluation of 68Ga-labeled peptide for PET imaging of NRP-1 and monitoring of the curative effect of breast cancer. European Journal of Nuclear Medicine and Molecular Imaging 2024, https://doi.org/10.1007/s00259-024-06632-x
76.Shiyu Zhu, Beibei Liang, Xuanyu Zhou, Yinfei Chen, Jiayu Fu, Ling Qiu*, Jianguo Lin*. Development of novel peptide-based radiotracers for detecting PD-L1 expression and guiding cancer immunotherapy. European Journal of Nuclear Medicine and Molecular Imaging 2024, 51: 625-640,https://doi.org/10.1007/s00259-023-06480-1
75.Xiaoqing Gao, Qianhui Wang, Xiaofeng Yang, Jing Fang, Huirong Li, Hongjie Xi, Jianguo Lin*, Ling Qiu*. Legumain-Triggered Macrocyclization of Radiofluorinated Probe for Enhanced PET Imaging. Bioconjugate Chem. 2024, https://doi.org/10.1021/acs.bioconjchem.4c00128
74.Jing Fang, Qingzhu Liu, Yaling Liu, Ke Li, Ling Qiu, Hongjie Xi, Shuyue Cai, Pei Zou*, Jianguo Lin*. β-Galactosidase-Activated and Red Light-Induced RNA Modification Strategy for Prolonged NIR Fluorescence/PET Bimodality Imaging. Anal. Chem. 2024, 96, 4, 1707-1716, https://doi.org/10.1021/acs.analchem.3c04845
73.Huirong Li, Beibei Liang, Xiaoqing Gao, Ying Peng, Qingzhu Liu, Ling Qiu, Jianguo Lin. Cathepsin B-Activated PET Tracer for in vivo Tumor Imaging. Mol. Pharmaceutics 2024, 21, 3, 1382-1389,
https://doi.org/10.1021/acs.molpharmaceut.3c01034
72.Sudong Kong, Qingzhu Liu, Yinfei Chen, Beibei Liang, Yuxuan Zhou, Shiyu Zhu, Jianguo Lin*, Ling Qiu*, Minhao Xie*. A multifunctional probe based on “chemical antibody-aptamer” for noninvasive detection of PD-L1 expression in cancer. Mol. Pharmaceutics 2024, 21, 1, 255-266, https://doi.org/10.1021/acs.molpharmaceut.3c00818
71.Chunmei Lu, Ke Li, Hongjie Xi, Di Hua, Huirong Li, Feng Gao*, Ling Qiu*, Jianguo Lin*. Dual-Targeting PET Tracers Enable Enzyme-Mediated Self-Assembly for PET Imaging of Legumain Activity. ACS Applied Materials & Interfaces 2023, 15(38): 44654-44664, https://doi.org/10.1021/acsami.3c07479
70.Huihui He, Ke Li, Hang Li, Shiliang Zhu, Shuai Qin, Yong Mao, Jianguo Lin, Ling Qiu*, Chunjing Yu*. Development of a multifunctional platform for near-infrared imaging and targeted radionuclide therapy for tumors. Eur. J. Pharm. Biopharm. 2023, 185, 107-115, https://doi.org/10.1016/j.ejpb.2023.02.013
69.Ying Peng, Qing-Zhu Liu, Dong Xu, Jia-Yu Fu, Li-Xia Zhang, Ling Qiu*, Jian-Guo Lin*. M4IDP stimulates ROS elevation through inhibition of mevalonate pathway and pentose phosphate pathway to inhibit colon cancer cells. Biochem Pharmacol. 2023, 217, 115856, https://doi.org/10.1016/j.bcp.2023.115856
68.Xin Hu, Gaochao Lv, Di Hua, Nan Zhang, Qingzhu Liu, Shuai Qin, Lixi Zhang, Hongji Xi, Ling Qiu*, Jianguo Lin*. Preparation and Bioevaluation of 18F-Labeled Small-molecular Radiotracers via Sulfur(VI) Fluoride Exchange Chemistry for Imaging of Programmed Cell Death Protein Ligand 1 Expression in Tumors. Mol. Pharmaceutics 2023, 20, 8, 4228–4235, https://doi.org/10.1021/acs.molpharmaceut.3c00355
67.Shiliang Zhu, Ke Li, Shuai Qin, Jianguo Lin*, Ling Qiu*. Cerenkov radiation induced Chemo-Photodynamic Therapy using ROS-responsive agent. J. Photochem. & Photobiol. A: Chemistry 2023，439，114641, https://doi.org/10.1016/j.jphotochem.2023.114641
66.Xidan Wen, Rui Zhang, Yuxuan Hu, Luyan Wu, He Bai, Dongfan Song, Yanfeng Wang, Ruibing An, Jianhui Weng, Shuren Zhang, Rong Wang, Ling Qiu, Jianguo Lin, Guandao Gao, Hong Liu*, Zijian Guo*, Deju Ye*. Controlled sequential in situ self-assembly and disassembly of a fluorogenic cisplatin prodrug for cancer theranostics. Nature Communications, 2023, 14, 800. https://doi.org/10.1038/s41467-023-36469-1
65.徐慧婷，王秀婷，寇永强，邱玲，林建国*，倪建明*。PET凋亡探针18F-1对三阴性乳腺癌放疗反应监测的实验研究. 中华核医学与分子影像杂志, 2023, 43(5), 290-294, DOI:10.3760/cma.j.cn321828-20220207-00032.
64.Yinfei Chen#, Shiyu Zhu#, Jiayu Fu, Jianguo Lin, Yan Sun, Gaochao Lv, Minhao Xie, Tao Xu*, Ling Qiu*. Development of a radiolabeled site-specific single-domain antibody positron emission tomography probe for monitoring PD-L1 expression in cancer. J. Pharm. Anal. 2022, 12, 869-878, https://doi.org/10.1016/j.jpha.2022.09.001
63.陈银飞，陈盼盼，朱诗宇，梁蓓蓓，谢敏浩，林建国，邱玲*。程序性死亡蛋白配体-1（PD-L1）靶向单域抗体的定点标记及生物学性质评价，中华核医学与分子影像杂志，2022，42(12), 744-750, DOI: 10.3760/cma.j.cn321828-20220509-0015
62.Ruibing An, Lingjun Liu, Shixuan Wei, Zheng Huang, Ling Qiu, Jianguo Lin, Hong Liu*, Deju Ye*. Controlling disassembly of paramagnetic prodrugs and photosensitizers nanoassemblies for on-demand orthotopic gliomas theranostics. ACS Nano 2022, 16, 12, 20607-20621, https://doi.org/10.1021/acsnano.2c07491
61.Jingyun Ren, Shiyu Zhu, Guojin Zhang, Xiaoyue Tan, Ling Qiu, Jianguo Lin*, Lei Jiang*. 68Ga-Labeled Cystine Knot Peptide Targeting Integrin αvβ6 for Lung Cancer PET Imaging. Mol. Pharmaceutics 2022, 19, 2620-2628, https://doi.org/10.1021/acs.molpharmaceut.2c00313
60.Qingzhu Liu#, Xiaodan Wang#, Yanling Yang, Chao Wang, Jian Zou*, Jianguo Lin*, Ling Qiu*. Immuno-PET imaging of PD-L1 expression in patient-derived lung cancer xenografts with [68Ga]Ga-NOTA-Nb109. Quant Imaging Med Surg 2022; 12(6): 3300-3313, https://doi.org/10.21037/qims-21-991
59.Qiqi Wang, Chunmei Lu, Ke Li, Yongmei Xia*, Ling Qiu*, Jianguo Lin*. Legumain-mediated self-assembly of a 131I-labelled agent for targeted radiotherapy of tumors. J. Mater. Chem. B, 2022, 10, 2251-2259,
https://doi.org/10.1039/d1tb02862f
58.Yuqi Wang, He Bai, Yinxing Miao, Jianhui Weng, Zheng Huang, Jiayu Fu, Yan Zhang*, Jianguo Lin*, Deju Ye*. Tailoring a Near-Infrared Macrocyclization Scaffold Allows the Control of In Situ Self-Assembly for Photoacoustic/PET Bimodal Imaging. Angew. Chem. Int. Ed. 2022, 61, e202200369, https://doi.org/10.1002/anie.202200369
57.Jianguo Lin*, Dingyao Gao, Shijie Wang, Gaochao Lv, Xiuting Wang, Chunmei Lu, Ying Peng, Ling Qiu*. Stimuli-Responsive Macrocyclization Scaffold Allows In Situ Self-Assembly of Radioactive Tracers for Positron Emission Tomography Imaging of Enzyme Activity. J. Am. Chem. Soc. 2022, 144, 17, 7667-7675, https://doi.org/10.1021/jacs.1c12935
56.Ling Qiu, Ke Li, Wenyi Dong, Yann Seimbille, Qingzhu Liu, Feng Gao*, Jianguo Lin*. Tumor Microenvironment Responsive “Head-to-Foot” Self-Assembly Nanoplatform for Positron Emission Tomography Imaging in Living Subjects. ACS Nano 2021, 15, 18250-18259, https://doi.org/10.1021/acsnano.1c07275
55.Yuxuan Hu, Yinxing Miao, Junya Zhang, Yinfei Chen, Ling Qiu, Jianguo Lin*, Deju Ye*. Alkaline Phosphatase Enabled Fluorogenic Reaction and in situ Coassembly of Near-Infrared and Radioactive Nanoparticles for in vivo Imaging, Nano Lett. 2021, 21, 10377-10385, https://doi.org/10.1021/acs.nanolett.1c03683
54.Yuxuan Hu, Junya Zhang, Yinxing Miao, Xidan Wen, Jian Wang, Yidan Sun, Yinfei Chen, Jianguo Lin, Ling Qiu*, Kai Guo*, Hong-Yuan Chen, Deju Ye*. Enzyme-mediated in situ self-assembly promotes in vivo bioorthogonal reaction for pretargeted multimodality imaging. Angew. Chem. Int. Ed., 2021, 60, 18082-18093, https://doi.org/10.1002/anie.202103307
53.Gaochao Lv#, Yinxing Miao#, Yinfei Chen, Chunmei Lu, Xiuting Wang, Minhao Xie, Ling Qiu*, Jianguo Lin*. Promising potential of a 18F-labelled small-molecular radiotracer to evaluate PD-L1 expression in tumors by PET imaging. Bioorganic Chemistry, 2021, 115, 105294, https://doi.org/10.1016/j.bioorg.2021.105294
52.Ke Li, Wenyi Dong, Yinxing Miao, Qingzhu Liu, Ling Qiu*, Jianguo Lin*. Dual-targeted 5-aminolevulinic acid derivatives with glutathione depletion function for enhanced photodynamic therapy. Journal of Photochemistry & Photobiology, B: Biology 2021, 215, 112107-112116, https://doi.org/10.1016/j.jphotobiol.2020.112107
51.Qingzhu Liu, Lei Jiang, Ke Li, Hang Li, Gaochao Lv, Jianguo Lin*, Ling Qiu*. Immuno-PET imaging of 68Ga-labeled nanobody Nb109 for dynamic monitoring the PD-L1 expression in cancers. Cancer Immunology Immunotherapy 2021, 70, 1721-1733, https://doi.org/10.1007/s00262-020-02818-y
50.Hang Li, Xiuting Wang, Yingxin Miao, Qingzhu Liu, Ke Li, Jianguo Lin, Minhao Xie*, Ling Qiu*. Development of biotin-tagged near-infrared fluorescence probes for tumor-specific imaging. Journal of Photochemistry & Photobiology, B: Biology 2021, 217, 112172, https://doi.org/10.1016/j.jphotobiol.2021.112172
49.Yinxing Miao#, Gaochao Lv#, Yinfei Chen, Ling Qiu, Minhao Xie*, Jianguo Lin*. One-Step Radiosynthesis and Initial Evaluation of a Small Molecule PET Tracer for PD-L1 Imaging. Bioorg. Med. Chem. Lett. 2020, 30, 127572-127576, https://doi.org/10.1016/j.bmcl.2020.127572
48.Yuqi Wang, Jianhui Weng, Jianguo Lin, Deju Ye, Yan Zhang*. NIR Scaffold Bearing Three Handles for Biocompatible Sequential Click Installation of Multiple Functional Arms. J. Am. Chem. Soc. 2020, 142, 6, 2787-2794, https://doi.org/10.1021/jacs.9b10467
47.Ling Qiu#, Xi Li#, Gaochao Lv#, Yann Seimbille, Ke Li, Ying Peng, Qingzhu Liu, Minhao Xie*, Jianguo Lin*. Radiofluorinated smart probes for noninvasive PET imaging of legumain activity in living subjects. Anal. Chem. 2020, 92, 11627-11634, https://doi.org/10.1021/acs.analchem.0c01253
46. Gaochao Lv,# Xiaorong Sun,# Ling Qiu*, Yan Sun, Ke Li, Qingzhu Liu, Qi Zhao, Songbing Qin*, Jianguo Lin*. PET imaging of tumor PD-L1 expression with a highly specific non-blocking nanobody. J. Nucl. Med., 2020, 61, 117-122. https://doi.org/10.2967/jnumed.119.226712
45. Siqing Ye,# Shijie Wang,# Dingyao Gao, Ke Li, Qingzhu Liu, Bainian Feng,* Ling Qiu,* Jianguo Lin*. A New γ-Glutamyltranspeptidase-Based Intracellular Self-Assembly of 18F-Labeled Probe for Enhancing PET Imaging in Tumors. Bioconjugate Chem. 2020, 31, 174-181. https://doi.org/10.1021/acs.bioconjchem.9b00803
44. Xueyu Zhao,# Gaochao Lv,# Ke Li, Ying Peng, Qingzhu Liu, Ling Qiu,* Jianguo Lin*. One-step 18F-fluorination of smart positron emission tomography probe for sensing furin activity in tumors. Nucl. Med. Biol. 2020, 82-83, 72-79. https://doi.org/10.1016/j.nucmedbio.2020.02.010
43. Qingzhu Liu, Yinxing Miao, Gaochao Lv, Ying Peng, Ke Li, Ling Qiu*, Jianguo Lin*. Structure-based virtual screening and biological evaluation of novel non-bisphosphonate farnesyl pyrophosphate synthase inhibitors. Eur. J. Med. Chem., 2020,186, 1-13. https://doi.org/10.1016/j.ejmech.2019.111905
42. Ling Qiu, Wei Wang, Ke Li, Ying Peng, Gaochao Lv, Qingzhu Liu, Feng Gao, Yann Seimbille, Minhao Xie*, Jianguo Lin*. Rational design of caspase-responsive smart molecular probe for positron emission tomography imaging of drug-induced apoptosis. Theranostics 2019, 9(23), 6962-6975. https://www.thno.org/v09p6962.htm
41. Ke Li, Wenyi Dong, Ling Qiu, Qingzhu Liu, Gaochao Lv, Ying Peng, Minhao Xie*, Jianguo Lin*. A new GSH-responsive prodrug of 5-aminolevulinic acid for diagnosis and photodynamic therapy of tumors. Eur. J. Med. Chem., 2019, 181, 1-9. https://doi.org/10.1016/j.ejmech.2019.111582
40. Xi Li, Qingzhu Liu, Ke Li, Gaochao Lv, Ying Peng, Ling Qiu*, Jianguo Lin*. A protease-responsive fluorescent probe for sensitive imaging of legumain activity in living tumor cells. Chem. Biol. Drug Des., 2019, 94(2), 1494-1503. https://doi.org/10.1111/cbdd.13530
39. Gaochao Lv, Ling Qiu*, Ke Li, Qingzhu Liu, Xi Li, Ying Peng, Shijie Wang, Jianguo Lin*. Enhancement of therapeutic effect in breast cancer with a steroid-conjugated ruthenium complex. New J. Chem. 2019, 43, 3419-3427. https://doi.org/10.1039/C8NJ04159H
38. Ke Li, Wenyi Dong, Qingzhu Liu, Gaochao Lv, Minhao Xie, Xinchen Sun, Ling Qiu*, Jianguo Lin*. A biotin receptor-targeted silicon(IV) phthalocyanine for in vivo tumor imaging and photodynamic therapy. J. Photochem. Photobiol. B. 2019, 190, 1-7. https://doi.org/10.1016/j.jphotobiol.2018.09.001
37. Hongbo Huang, Ke Li, Qingzhu Liu, Yunlei Zhao, Huiting Xu, Wenjuan Wu, Kairong Sun, Jianming Ni*, Jianguo Lin*. Dual-response CuS@MnO2 nanoparticles with activatable CT/MR-enhanced in vivo imaging guided photothermal therapy. RSC Adv. 2019, 9, 2718-2730. https://doi.org/10.1039/c8ra08637k
36. Ling Yin, Hao Sun, Hao Zhang, Lei He, Ling Qiu, Jianguo Lin, Huawei Xia, Yuqi Zhang, Shunjun Ji*, Haibin Shi*, Mingyuan Gao*. Quantitatively Visualizing Tumor-Related Protease Activity in Vivo Using a Ratiometric Photoacoustic Probe. J. Am. Chem. Soc. 2019, 141(7), 3265-3273. https://doi.org/10.1021/jacs.8b13628
35. Gaochao Lv, Ke Li, Ling Qiu*, Ying Peng, Xueyu Zhao, Xi Li, Qingzhu Liu, Shanshan Wang, Jianguo Lin*. Enhanced Tumor Diagnostic and Therapeutic Effect of Mesoporous Silica Nanoparticle-Mediated Pre-targeted Strategy. Pharm. Res. 2018, 35(3), 63-74. https://doi.org/10.1007/s11095-017-2338-5
34. Zhiliang Luo, Zheng Huang, Ke Li, Yidan Sun, Jianguo Lin*, Deju Ye*, Hongyuan Chen. Targeted Delivery of γ-Glutamyl Transpeptidase Activatable Near-Infrared-Fluorescent Probe for Selective Cancer Imaging. Anal. Chem. 2018, 90(4), 2875-2883. https://doi.org/10.1021/acs.analchem.7b05022
33. Xueyu Zhao, Gaochao Lv, Ying Peng, Qingzhu Liu, Xi Li, Shanshan Wang, Ke Li, Ling Qiu*, Jianguo Lin*. Targeted Delivery of an Activatable Fluorescent Probe for the Detection of Furin Activity in Living Cells. ChemBioChem 2018, 19, 1060-1065. https://doi.org/10.1002/cbic.201800015
32. Anping Ji, Yuanchao Zhang, Gaochao Lv, Jianguo Lin, Ning Qi, Faquan Ji, Minghua Du*.131I Radiolabeled immune albumin nanospheres loaded with doxorubicin for in vivo combinatorial therapy. J. Label. Compd. Radiopharm. 2018, 61, 362-369. https://doi.org/10.1002/jlcr.3593
31. Hongbo Huang, Ke Li, Gaochao Lv, Guiqing Liu, Xueyu Zhao, Qingzhu Liu, Shanshan Wang, Xi Li, Ling Qiu*, Jianguo Lin*. One-step 18F-labeling of estradiol derivative for PET imaging of breast cancer. Contrast Media & Molecular Imaging 2018, 1-9. https://doi.org/10.1155/2018/5362329
30. QingZhu Liu, ShanShan Wang, Xi Li, XueYu Zhao, Ke Li, GaoChao Lv, Ling Qiu*, JianGuo Lin*. 3D-QSAR, Molecular Docking and ONIOM Studies on the Structure-Activity Relationships and Action Mechanism of Nitrogen-Containing Bisphosphonates.Chem. Biol. Drug. Des. 2018, 91(3), 735-746. https://doi.org/10.1111/cbdd.13134
29. Shanshan Wang, Qingzhu Liu, Xi Li, Xueyu Zhao, Ling Qiu*, Jianguo Lin*. Possible binding sites and interactions of propanidid and AZD3043 within the γ-aminobutyric acid type A receptor (GABAAR). J. Biomol. Struct. Dyn. 2018, 36(15), 3926-3937. https://doi.org/10.1080/07391102.2017.1403959
28. Qingzhu Liu, Ke Li, Gaochao Lv, Xi Li, Ying Peng, Jianguo Lin*, Ling Qiu*. Density functional theory studies on a non-covalent interaction system: hydrogen-bonded dimers of zoledronate. J. Mol. Model. 2018, 24(11), 310-325. https://doi.org/10.1007/s00894-018-3826-1
27. Jianguo Lin*, Wei Wang, Ke Li, Hongbo Huang, Gaochao Lv, Shineng Luo, Ling Qiu*. Development of a kit-like radiofluorinated biomolecule to controlled self-assembly of 18F nanoparticles under reducing environment for a smart PET imaging application. Chem. Commun. 2017, 53, 6476-6479. https://doi.org/10.1039/C7CC03040A
26. Ling Qiu, Jianguo Lin, Qingzhu Liu, Shanshan Wang, Gaochao Lv, Ke Li, Haiming Shi, Zhengkun Huang, Edward J. Bertaccini*. The Role of the Hydroxyl Group in Propofol-Protein Target Recognition: Insights from ONIOM Studies. J. Phys. Chem. B 2017, 121, 5883-5896. https://doi.org/10.1021/acs.jpcb.7b02079
25. Ying Peng, Ling Qiu, Dong Xu, Li Zhang, Huixin Yu, Yuedi Ding, Lili Deng, Jianguo Lin*. M4IDP, a zoledronic acid derivative, induces G1 arrest, apoptosis and autophagy in HCT116 colon carcinoma cells via blocking PI3K/Akt/mTOR pathway. Life Sci. 2017, 185, 63-72. https://doi.org/10.1016/j.lfs.2017.07.024
24. Ke Li, Ling Qiu*, Qingzhu Liu, GaochaoLv, Xueyu Zhao, Shanshan Wang, Jianguo Lin*. Conjugate of biotin with silicon(IV) phthalocyanine for tumor-targeting photodynamic therapy. J. Photochem. Photobiol. B. 2017, 174, 243-250. https://doi.org/10.1016/j.jphotobiol.2017.08.003
23. Ling Qiu, Hui Yang, Gaochao Lv, Ke Li, Guiqing Liu, Wei Wang, Shanshan Wang, Xueyu Zhao, Minhao Xie, Jianguo Lin*. Insights into the mevalonate pathway in the anticancer effect of platinum complex on human gastric cancer cells. Eur. J. Pharmacol. 2017, 810, 120-127. https://doi.org/10.1016/j.ejphar.2017.06.035
22. Jianguo Lin*, Ling Qiu, Gaochao Lv, Ke Li, Wei Wang, Guiqing Liu, Xueyu Zhao, Shanshan Wang. Synthesis and preliminary biological evaluation of a 99mTc-chlorambucil derivative as a potential tumor imaging agent. J. Labelled. Comp. Radiopharm. 2017, 60(2), 116-123. https://doi.org/10.1002/jlcr.3481
21. Guiqing Liu, Wei Wang, Jianguo Lin*, Ke Li, Gaochao Lv, Xueyu Zhao, Shanshan Wang, Shineng Luo, Ling Qiu*. Kit-like 18F-labeling of an estradiol derivative as a potential PET imaging agent for estrogen receptor-positive breast cancer. J. Radioanal. Nucl. Chem. 2017, 312, 599-607. https://doi.org/10.1007/s10967-017-5245-7
20. Yang Zhao, Xiaoyue Xu, Ling Qiu, Xiaojing Kang, Lili Wen*, Bingguang Zhang*. Metal-Organic Frameworks Constructed from a New Thiophene-Functionalized Dicarboxylate: Luminescence Sensing and Pesticide Removal. ACS Appl. Mater. Interfaces 2017, 9, 15164-15175. https://doi.org/10.1021/acsami.6b11797
19. Gaochao Lv, Ling Qiu*, Guiqing Liu, Wei Wang, Ke Li, Xueyu Zhao, Jianguo Lin*. pH sensitive chitosan-mesoporous silica nanoparticles for targeted delivery of a ruthenium complex with enhanced anticancer effects. Dalton. Trans. 2016, 45,18147-18155. https://doi.org/10.1039/C6DT03783F
18. Liubin Guo, Gaochao Lv, Ling Qiu*, Hui Yang, Li Zhang, Huixin Yu, Meifen Zou, Jianguo Lin*. Insights into anticancer activity and mechanism of action of a ruthenium(II) complex in human esophageal squamous carcinoma EC109 cells. Eur. J. Pharmacol. 2016, 786, 60-71. https://doi.org/10.1016/j.ejphar.2016.05.042
17. Qingzhu Liu, Ling Qiu*, Yang Wang, Gaochao Lv, Guiqing Liu, Shanshan Wang, JianguoLin*. Solvent effect on molecular structure, IR spectra, thermodynamic properties and chemical stability of zoledronic acid: DFT study. J. Mol. Model. 2016, 22(4), 1-11. https://doi.org/10.1007/s00894-016-2953-9
16. Saifei Xi, Lingyu Bao, JianguoLin, Qingzhu Liu, Ling Qiu, Fengli Zhang, Yuxia Wang, Zhengdong Ding, Zhiguo Gu*. Enantiomers of tetrahedral metal-organic cages: a new class of highly efficient G-quadruplex ligands with potential anticancer activities. Chem. Commun. 2016, 52, 10261-10264. https://doi.org/10.1039/C6CC05743H
15. Ling Qiu, GaochaoLv, Liubin Guo, Liping Chen, Shineng Luo, Meifen Zou, Jianguo Lin*. Synthesis, crystal structure and antitumor effect of a novel copper(II) complex bearing zoledronic acid derivative.Eur. J. Med. Chem. 2015, 89, 42-50. https://doi.org/10.1016/j.ejmech.2014.10.028
14. GaochaoLv, Liubin Guo, Ling Qiu*, Hui Yang, Tengfei Wang, Hong Liu, Jianguo Lin*. Lipophilicity-dependent ruthenium N-heterocyclic carbene complexes as potential anticancer agents. Dalton. Trans. 2015, 44, 7324-7331. https://doi.org/10.1039/C5DT00169B
13. Ling Qiu, JianguoLin, Edward Bertaccini*. Insights into the Nature of Anesthetic-Protein Interactions: An ONIOM Study. J. Phys. Chem. B 2015, 119, 12771-12782. https://doi.org/10.1021/acs.jpcb.5b05897
12. Ling Qiu, Gaochao Lv, Yang Cao, Liping Chen, Hui Yang, Shineng Luo*, Meifen Zou, Jianguo Lin*. Synthesis and biological evaluation of novel platinum complexes of imidazolyl-containing bisphosphonates as potential anticancer agents. J. Biol. Inorg. Chem. 2015, 20, 1263-1275. https://doi.org/10.1007/s00775-015-1305-z
11. Mikael Palner, Bin Shen, Jongho Jeon, Jianguo Lin, Frederick T. Chin, Jianghong Rao*. Preclinical Kinetic Analysis of the Caspase-3/7 PET Tracer F-18-C-SNAT: Quantifying the changes in blood flow and tumor retention after chemotherapy. J. Nucl. Med. 2015, 56(9), 1415-1421. https://doi.org/10.2967/jnumed.115.155259
10. Yang Wang, Qingzhu Liu, Ling Qiu*, Tengfei Wang, Haoliang Yuan, Jianguo Lin, Shineng Luo*. Molecular structure, IR spectra, and chemical reactivity of Cisplatin and Transplatin: DFT studies, basis set effect and solvent effect. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2015, 150, 902-908. https://doi.org/10.1016/j.saa.2015.06.027
9. Qingzhu Liu, Yang Wang, Ling Qiu*, Tengfei Wang, Shineng Luo, Haoliang Yuan, Jianguo Lin*. Theoretical Studies on the Structural, Spectroscopic, Thermodynamic, and Electronic Properties of Zoledronic Acid. J. Struct. Chem. 2015, 56(7), 1313-1324. https://doi.org/10.1134/S0022476615070124
8. Ling Qiu, Qingzhu Liu, Yang Wang, Tengfei Wang, Hui Yang, Xuehai Ju, Shineng Luo, Jianguo Lin*. DFT Investigations on the Structure and Properties of MBP Dimers and Crystal with Strong Hydrogen-Bonding Interactions. Struct. Chem. 2015, 26(3), 845-858.
7. Ling Qiu, Jianguo Lin*, Beibei Nan, Gaochao Lv, Wen Cheng. Pharmacokinetic and imaging evaluation of 99mTc-HBIDP as a potential bone imaging agent. Pak. J. Pharm. Sci. 2015, 28(3), 815-818.
6. Ling Qiu, Jianguo Lin*, Liqing Wang, Wen Cheng, Yang Cao, Xuewen Liu, Shineng Luo. A Series of Imidazolyl-Containing Bisphosphonates with Abundant Hydrogen-Bonding Interactions: Syntheses, Structures and Bone-Binding Affinity. Aust. J. Chem. 2014, 67, 192-205. https://doi.org/10.1071/CH13194
5. Deju Ye, Prachi Pandit, Paul Kempen, JianguoLin, Liqin Xiong, Robert Sinclair, Brian Rutt, Jianghong Rao*. Redox-Triggered Self-Assembly of Gadolinium-Based MRI Probes for Sensing Reducing Environment. Bioconjugate Chem. 2014, 25(8), 1526-1536. https://doi.org/10.1021/bc500254g
4. Guangli Wang*, Xiufang Xu, Ling Qiu, Yuming Dong, Zaijun Li, Chi Zhang. Dual Responsive Enzyme Mimicking Activity of AgX (X = Cl, Br, I) Nanoparticles and Its Application for Cancer Cell Detection. ACS Appl. Mater. Interfaces 2014, 6(9), 6434-6442. https://doi.org/10.1021/am501830v
3. Ling Qiu, Jianguo Lin*, Wen Cheng, Yan Wang, Shineng Luo. 99mTc-labeled butyl-substituted zoledronic acid as a novel potential SPECT imaging agent: preparation and preclinical pharmacology study. Med. Chem. Res. 2013, 22, 6154-6162. https://doi.org/10.1007/s00044-013-0613-5
2. Ling Qiu, Wen Cheng, Jianguo Lin*, Shu Zhang, Shineng Luo. Synthesis and pharmacological evaluation of 99mTc-labeled imidazolyl-containing diphosphonic acid as a novel bone imaging agent. J. Label. Compd. Radiopharm. 2013, 56, 573-580. https://doi.org/10.1002/jlcr.3065
1. Ling Qiu, Wen Cheng, Jianguo Lin*, Liping Chen, Jun Yao, Wenwen Pu, Shineng Luo*. Synthesis and evaluation of a series of 99mTc-labelled zoledronic acid derivatives as potential bone seeking agent. J. Radioanal. Nucl. Chem. 2013, 295, 545-552. https://doi.org/10.1007/s10967-012-1883-y
